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doi: 10.1186/s12916-016-0745-9 39 GeorgakisMKDimitriouNGKaralexiMAMihasCNasothimiouEGTousoulisDet al

Biochem 214 , 829835 (1993)

and Coomber, B.L

This is a practical consideration for research settings where compound integrity directly affects the validity of experimental outcomes

Influence on the Inflammation Related AA Network Metabolite Distribution Previous studies have suggested that activating GPX4 is a promising strategy to suppress eicosanoid generation and inflammation ( Figure 1 , when GPX4 is up-regulated, an increase in 12-HETE and 15-HETE at the downstream of the 12-LOX and 15-LOX pathway, respectively, is envisioned

Macrophages constitute microglia [149], immune cells that represent 10% of the central nervous system [163], with an important role in the modeling and neurogenesis of neuronal circuits, having implications in the subsequent development of social behavior and cognitive function [149]